Cerebrovascular Function in Hormonal Migraine: An Exploratory Study

Background: Migraineurs, particularly young premenopausal women, are at increased risk of cerebrovascular disease; however, there is currently limited evidence as to whether hormonal migraine associated with poor function. Objectives: The objectives this study were to: (1) investigate the potential association function and (2) determine abnormalities in migraineurs migraine-related disability and/or quality life. Method: A cross-sectional was undertaken 50 (mean age: 38.7 ± 1.2 years) 29 controls 35.6 1.8 years). Data collected a single point time from all participants during inter-ictal period when they free not menstruating. Transcranial Doppler ultrasound used measure resting blood flow velocity responsiveness (CVR) hypercapnia cognitive stimulation (neurovascular coupling) left right middle cerebral artery (MCA). Additionally, completed three questionnaires assess life well frequency intensity: Headache Impact Test-6™, Migraine-Specific Quality Life Migraine Disability Assessment. Results: Hormonal had lower mean (MBFV) ( P = 0.009) neurovascular coupling 0.010) MCA than controls. No such differences found MCA. heart rate 0.004) higher However, no CVR between Multi-variate analysis revealed age be significant 0.012) predictor MBFV Negative correlations headache 0.026) 0.044) found. negative 2-Back 1.5 s task MSQoL emotional 0.013) role-function restrictive 0.039) domains Conclusions: This first show that have poorer function, represented by impaired Future studies should improving can prevent improve Clinical Trial Registration: ACTRN12618001230246.